mir-210: A Sensor for Hypoxic Stress during Tumorigenesis
نویسندگان
چکیده
منابع مشابه
miR-210: fine-tuning the hypoxic response.
Hypoxia is a central component of the tumor microenvironment and represents a major source of therapeutic failure in cancer therapy. Recent work has provided a wealth of evidence that noncoding RNAs and, in particular, microRNAs, are significant members of the adaptive response to low oxygen in tumors. All published studies agree that miR-210 specifically is a robust target of hypoxia-inducible...
متن کاملCombined prediction of miR‐210 and miR‐374a for severity and prognosis of hypoxic–ischemic encephalopathy
Background and Aim Hypoxic-ischemic encephalopathy (HIE) is a disorder featured by hypoxic and ischemic damages during the perinatal period and its high mortality (i.e., 15%-20%) could be partly attributed to late diagnosis. Therefore, miR-210 and miR-374a were investigated to find if they could improve the diagnostic values of S100B protein and neuron-specific enolase (NSE) for HIE. Methods ...
متن کاملEmerging roles of miR-210 and other non-coding RNAs in the hypoxic response.
Hypoxia is a key component of the tumor microenvironment and represents a well-documented source of therapeutic failure in clinical oncology. Recent work has provided support for the idea that non-coding RNAs, and in particular, microRNAs, may play important roles in the adaptive response to low oxygen in tumors. Specifically, all published studies agree that the induction of microRNA-210 (miR-...
متن کاملElevation of Circulating miR-210-3p in High-Altitude Hypoxic Environment
BACKGROUND The induction of miR-210-3p, a master hypoxamir, is a consistent feature of the hypoxic response in both normal and malignant cells. However, whether miR-210-3p acts as a circulating factor in response to a hypoxic environment remains unknown. The current study aimed to examine the effect of a high-altitude hypoxic environment on circulating miR-210-3p. METHODS We examined and comp...
متن کاملVisualization of exosome-mediated miR-210 transfer from hypoxic tumor cells
Cancer cells actively release exosomes carrying specific cellular components, such as proteins, mRNA, and miRNA, to communicate with various cells in the tumor microenvironment. We visualized exosome-mediated transfer of miR-210 from hypoxic breast cancer cells to neighboring cells using a miR-210 specific reporter system. By in vitro and in vivo visualization, we found that exosomes with miR-2...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2009
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2009.09.008